A biochemist at Columbia University, Erwin Chargaff discovered the base-pairing regularities or "complementarity relationships" of nucleic acids that provided one of the key steps in developing a structural model for DNA. During his long career, Chargaff is credited with conclusively falsifying the tetranucleotide hypothesis; demonstrating the existence of a large number of DNA species; and creating the first descriptions of hypochromicity, hyperchromicity, and the denaturation of a DNA. In addition, Chargaff conducted important research on blood coagulation, lipids and lipoproteins, the metabolism of amino acids and inositol, and the biosynthesis of phosphotransferases. He retired to emeritus status in 1974 and remained active in research almost to the time of his death in June 2002. The Chargaff Papers are organized into ten series: I. Correspondence, 1931-1992; Ia. Correspondence, 1949-2002; IIa. Grants, 1930-1982; IIb. Subject Files, 1940-1984; IIc. Subject Files, 1946-2002; III. Works by Chargaff, 1929-1989; IIIa. Works by Chargaff, 1923-2002; IIIb. Reprints, 1977-1999; IV. Works by Others, 1936-1985; IVa. Works by Others, 1976-2002; V. Research Notes and Notebooks, 1929-1951 ; VI. Photographs, 1935-1977; VIa. Photographs, 1928-2002; VII. Audiovisual Materials; VIII. Awards and Certificates, 1958-2001; IX. Lecture Notes, 1942-1985; X. Personal Papers, [1880]-1985.

This collection of correspondence, reports, and manuscripts concerns Stalker's research in genetics and evolutionary biology, particularly the evolutionary genetics of Drosophila. Most of the letters are scientific, although the usual academic politics in various departments is mentioned. There is also material on the Society for the Study of Evolution (1970).

A bacteriologist from MIT, Salvador E. Luria's work with Max Delbruck on bacteriophage demonstrated that bacterial resistance to certain phages arose through genetic mutations. His later work showed that phages also mutate genetically. He received the Nobel Prize in Physiology or Medicine in 1969 with Max Delbruck and Alfred D. Hershey. The collection is organized into seven series: I. Correspondence, 1938-1992 ; IIa. Subject Files, 1938-1990 ; IIb. Personal Material. 1923-1991 ; III. Works by Luria, 1938-1987 ; IV. Works by Others, 1944-1990 ; V. Research Notes and Notebooks, 1941-1979 ; VI. Course Material, 1931-1991 ; VII. Photographs and Negatives, 1957-1982. Arrangement: Alphabetical by folder title and then chronological within each folder.

Sewall Wright ranks among the most influential figures in the field of population genetics during the 20th century, and made important contributions to biostatistics, biometrics, and evolutionary theory. These papers contain much of Wright's professional correspondence, scattered research notes, and drafts of a small number of papers.

The James V. Neel Papers document nearly every phase of the career of one of the founders of human population genetics in the United States. Neel was particularly thorough and organized, and retained virtually all of his significant scientific correspondence, committee reports, minutes of meetings, and drafts of manuscripts. The collection also includes data collected during Neel's work among the Xavante, Yanomanö and other indigenous populations. In a career that spanned the period from the late work of Thomas Hunt Morgan and Charles B. Davenport to the contemporary world of molecular genetics and nucleic acids, Neel knew, worked with, and corresponded with many of the most influential 20th century practitioners of genetics. The collection begins in earnest in 1943, after Neel had decided to focus on human genetics. Neel's work with Drosophila and none of his Drosophila manuscripts are found in the collection.